婴儿先天性白内障摘出术后早期中央角膜厚度变化与眼压的相关性研究

目的　测量并观察生后１２个月以内行先天性白内障摘出术患儿术后术眼中央角膜厚度（ｃｅｎｔｒａｌｃｏｒｎｅａｌｔｈｉｃｋｎｅｓｓ，ＣＣＴ）及眼压（ｉｎｔｒａｌｏｃｕｌａｒｐｒｅｓｓｕｒｅ，ＩＯＰ）的变化。方法　选取２６例（４９眼）生后１２个月内行白内障摘出术的先天性白内障患儿为观察组，按行手术时月龄分为三组:１组:月龄≤３个月，２组:３个月＜月龄≤６个月；３组:６个月＜月龄≤１２个月。分别在术前、术后１个月、３个月、６个月时测量术眼ＣＣＴ与ＩＯＰ。另选取与各观察组最后一次随访时的患儿年龄与性别相匹配的相对正常眼婴幼儿作为对照组。结果　观察组术后１个月、３个月、６个月的ＣＣＴ为（５７８．３９±４７．７９）μｍ、（５８１．３４±５１．５４）μｍ、（５８８．２９±４９．９０）μｍ，均显著大于术前（５６３．５６±３７．１４）μｍ及对照组（５３４．９６±４０．３４）μｍ（均为Ｐ＜０．０５）。观察组术前、术后１个月、３个月、６个月ＩＯＰ测量值间差异无统计学意义（Ｐ＞０．０５），观察组术后６个月ＩＯＰ测量值大于对照组（Ｐ＜０．０５）。观察组术后６个月ＣＣＴ与ＩＯＰ线性相关（ｒ＝０．５３８，Ｐ＝０．００４）。结论　婴儿先天性白内障摘出术后早期的ＣＣＴ显著大于正常同龄婴儿，且与ＩＯＰ线性相关。

Central corneal thickness changes of infantal congenital cataracts and its correlation with intraocular pressure following extraction surgery

Objective To investigate the changes of central corneal thickness ( CCT) and intraocular pressure ( IOP) following congenital cataract extraction in infants within postnatal 12 months. Methods Follow-up investigation were studied in 26 cases(49 eyes) of infants with congenital cataract extraction operation within postnatal 12 months. According to the months .the infants with congenital cataract were divided into three groups :《 3 months group , 3 - 6 months group ,6 - 12 months group. IOP and CCT in the operated eyes at pre-operation and postoperative I month .3 months and 6 months were detected. The relative normal infants with the age and gender matched with the infants in each observation group at the final follow-up were chosen as the control group. Results CCT in the observation group at postoperative I month. 3 months and 6 months were ( 578. 39 + 47. 79 ) ym , ( 581. 34 + 51. 54) ym and ( 588. 29 + 49. 90 ) ym , respectively , which were higher than the pre-operation ( 563. 56 + 37. 14 ) ym and control group ( 534. 96 + 40. 34 ) ym ( all P < 0. 05 ) . There was no statistical difference in IOP among pre-operation , postoperative I month ,3 months and 6 months ( P > 0. 05 ) . and IOP in the observation group at postoperative 6 months was higher than that in the control group(P < 0. 05 ) . There was a linear correlation between CCT and IOP in the observation group ( r = 0. 538 .P = 0. 004 ) . Conclusion CCT at the early postoperative time following cataract extraction is obviously higher than the same aged normal infants,and CCT is increased in eyes undergoing congenital cataract surgery when the surgery is performed at an early age. CCT is linear correlated with IOP.