| 骨桥蛋白预测早期非小细胞肺癌患者预后的意义 |
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| 引用本文： | 吕梦果,颜次慧,宋新苗,曹水.骨桥蛋白预测早期非小细胞肺癌患者预后的意义[J].肿瘤防治研究,2015,42(4):340-344. |
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| 作者姓名： | 吕梦果 颜次慧 宋新苗 曹水 |
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| 作者单位： | 1. 300060天津，天津医科大学肿瘤医院免疫室， 国家肿瘤临床医学研究中心，天津市肿瘤免疫与生物治疗重点实验室，天津市“肿瘤防治”重点实验室；2.300060 天津，天津医科大学肿瘤医院生物治疗科 |
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| 基金项目： | 天津市应用基础与前沿技术研究计划（14JCQNJC111500）；天津医科大学科学基金（2012KYM03）；天津市肿瘤医院博士启动基金（B1204） |
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| 摘 要： | 目的 探讨骨桥蛋白（osteopontin，OPN）在非小细胞肺癌（non-small cell lung cancer，NSCLC）中的表达和预后意义。方法 采用免疫组织化学法检测84例非小细胞肺癌组织中OPN表达情况，利用χ 2检验和Kaplan-Meier生存曲线分析OPN表达与临床病理相关因素及患者术后总生存时间（overall survival，OS）、无疾病生存时间（disease-free survival，DFS）的关系。结果 84例非小细胞肺癌组织中OPN阳性表达率为83.3%（70/84）。在早期患者中，OPN阴性表达组DFS和OS长于OPN阳性组（χ 2=9.722，P=0.019；χ 2=6.064，P=0.014）。而晚期患者OPN阴性表达组DFS和OS与阳性组间比较差异无统计学意义。结论 非小细胞肺癌组织中存在OPN表达，OPN可能成为预测早期NSCLC患者预后的参考指标。
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| 关 键 词： | 骨桥蛋白 非小细胞肺癌 免疫组织化学 预后 |
| 收稿时间： | 2014-09-05 |
Osteopontin Predicts Prognosis of Early Stage Non-small Cell Lung Cancer Patients |
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| LV Mengguo,YAN Cihui,SONG Xinmiao,CAO Shui.Osteopontin Predicts Prognosis of Early Stage Non-small Cell Lung Cancer Patients[J].Cancer Research on Prevention and Treatment,2015,42(4):340-344. |
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| Authors: | LV Mengguo YAN Cihui SONG Xinmiao CAO Shui |
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| Institution: | 1. Department of Immunology, Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center of Cancer, Key Laboratory of Cancer Immunology and Biotherapy Tianjin, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China; 2. Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China |
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| Abstract: | Objective To investigate the expression of osteopontin (OPN) in non-small cell lung cancer (NSCLC) tissues and its relationship with the prognosis of patients. Methods Immunohistochemistry (IHC) was applied to detect OPN expression in 84 cases of NSCLC tissues. The relationship between OPN expression and clinicopathological factors, overall survival(OS), disease-free survival(DFS) of the patients were analyzed by Chi-square test and Kaplan-Meier survival curve. Results The expression of OPN was 83.3% (70/84) in 84 cases of NSCLC tissues. Moreover, for patients with tumor-node-metastasis (TNM) stage, OS and DFS in OPN negative group were significantly higher than those in OPN positive group (χ 2=9.722, P=0.019; χ 2=6.064, P=0.014), however, there was no significance between the expression of OPN and the prognosis of patients with advanced stage NSCLC. Conclusion OPN is commonly expressed in NSCLC tissues and could be a novel prognostic biomarker for early stage NSCLC patients. |
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| Keywords: | Osteopontin Non-small cell lung cancer(NSCLC) Immunohistochemistry Prognosis |
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