联合检测血清 DJ-1 和 CA125 在上皮性卵巢肿瘤中的意义

目的 研究血清 DJ-1 蛋白联合 CA125 在上皮性卵巢肿瘤诊断中的应用价值。方法 采用双抗体夹心法和电化学发光法测定 82 例上皮性卵巢肿瘤患者 （包括良性卵巢肿瘤 16 例， 交界性卵巢肿瘤 14 例， 卵巢癌 52 例） 与80 例同期住院的其他良性妇科疾病患者（对照组）血清 DJ-1、 CA125 水平， 分析两种标志物联合检测在诊断卵巢癌中的意义。结果 卵巢肿瘤患者血清 DJ-1 和 CA125 水平明显高于对照组（P＜0.05）； 以对照组和非卵巢癌组进行参照， 血清 DJ-1 在卵巢癌中的临界值分别为 6.800 μg/L 和 6.965 μg/L； 联合检测血清 DJ-1 和 CA125 的敏感度高于单项检测指标。结论 DJ-1 和 CA125 联合检测有助于卵巢癌的诊断， 可作为很好的卵巢癌标志物， 提高早期卵巢癌的诊断率。

The significance of detecting serum DJ-1 protein combined with CA125 in epithelial ovarian tumors

Objective To explore the diagnostic value of detecting serum DJ-1 protein combined with CA125 for epithelial ovarian tumors. Methods Double antibody sandwich method and electrochemiluminescence immunoassay were used to determine the serum levels of DJ-1 protein and CA125 in 82 cases of epithelial ovarian tumors and 80 non-ovarian tumor cases (control group). The clinical significance of detecting serum DJ-1 protein combined with CA125 was analyzed. Results The expression levels of DJ-1 and CA125 were significantly higher in ovarian tumor group than those in the control group (P＜0.05). The critical value of serum DJ-1 was 6.800 μg/L and 6.965 μg/L in ovarian cancer group compared with the control group and non-ovarian tumor group. The sensitivity of combined detection of DJ-1 and CA125 was higher than that of any marker alone. Conclusion The detecting serum levels of DJ-1 combined with CA125 are helpful to the diagnosis of ovarian cancer, which can be a good marker of ovarian cancer and may improve the early diagnosis rate of ovarian cancer.