无防腐剂滴眼液包装瓶的问题与改进

随着对滴眼液中防腐剂毒性作用的关注，无防腐剂滴眼液应运而生。目前，滴眼液中不加防腐剂，主要是通过包装瓶的改进而达到的，从单剂量包装瓶到多剂量包装瓶，各有其优劣。单剂量包装瓶携带方便，开启后暴露时间短，可基本避免微生物污染，但生产成本高，易导致滴眼液浪费增加。多剂量包装瓶，既做到了无防腐剂，又能多次使用，但需要患者改变使用习惯，对滴眼液的黏滞度也有一定要求，且眼药瓶本身的生产成本比例增大。随着对滴眼剂包装瓶研究设计的深入，滴眼液包装瓶应旨在安全简便、成本“亲民”、剂量可控。

Problem and improvement of the bottles of preservative-free eye drops

With the focus on the role of preservative in eye drops, preservative-free eye drops came into being. At present, there is no preservative in eye drops following the improvement of the packaging bottle. From a single dose to a multi dose packaging bottle, each has its advantages and disadvantages. Single dose packaging bottle is convenient to carry and can basically avoid microbial contamination because of the short exposure time. But the production cost is high and can lead to the waste of eye drops. Multi-dose packaging bottle can achieve preservatives-free, and can be used repeatedly. But patients need to change using habits. It needs certain viscosity of eye drops, and the ratio of bottle production cost increases. With the deeper study, eye drop bottles should be designed to be more safe, convenient, cost-effective and dose-controllable.