肿瘤相关巨噬细胞在肿瘤微环境中的作用新进展

众所周知，在肿瘤发生发展的各个阶段都有单核细胞通过血管壁进入肿瘤组织，这些单核细胞可分化形成具有独特表型的巨噬细胞，即肿瘤相关巨噬细胞（tumor-associated macrophages,TAMs）。TAMs是肿瘤微环境的重要组成部分，参与了肿瘤的发生、生长、侵袭及转移过程，其中，向肿瘤组织的转移是肿瘤恶性发展的关键步骤。本文将TAMs在肿瘤微环境形成中发挥作用的最新进展进行了总结，特别值得注意的是，细胞及动物实验研究表明，TAMs可为肿瘤的发生发展进程提供一个有利的微环境；同时，临床病理实验表明，TAMs在肿瘤内的累积与较差的临床疗效相关。最后，本文讨论了靶向TAMs的治疗手段作为一种间接癌症治疗新方法的可行性。

New Progress on Tumor-associated Macrophages in Tumor Microenvironment

As we all know, monocytes can enter into the tumor tissues through the blood vessel wall at the various stages of tumor development. These monocytes can differentiate into macrophages, i.e. the tumor-associated macrophages(TAMs), with unique phenotypes. TAMs are important parts of the tumor microenviroment, involved in tumorigenesis, growth, invasion and metastasis, moreover, TAMs transferring into the tumor tissues is a critical step in the development of malignant tumors. In this review, the latest advances of TAMs on tumor microenvironment have been discussed noticeably, cell and animal studies proved that TAMs could make a favorable microenvironment to promote tumor development and progression. Meanwhile, clinicopathological studies suggest that the accumulation of TAMs in tumors is correlated with poor clinical outcome. At last, we also discuss the possibility of using TAM-targeting therapy as a promising novel strategy for cancer therapy.