| 纳米金颗粒的基本特性及其对肿瘤放射增敏作用的研究进展 |
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| 引用本文： | 朱传东,王礼学,郑勤,吴剑卿. 纳米金颗粒的基本特性及其对肿瘤放射增敏作用的研究进展[J]. 肿瘤防治研究, 2015, 42(7): 720-724. DOI: 10.3971/j.issn.1000-8578.2015.07.017 |
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| 作者姓名： | 朱传东 王礼学 郑勤 吴剑卿 |
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| 作者单位： | 1. 210003南京，东南大学附属第二医院肿瘤科；2. 210029南京，南京医科大学第一附属医院老年呼吸科 |
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| 基金项目： | 国家自然科学基金（30971320, 81272602）；南京市医学科技发展项目重点课题（ZKX13019） |
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| 摘 要： | 纳米金颗粒以其独特的理化性质在医学领域越来越受到重视。近年许多研究证实了纳米金在肿瘤治疗中可以减少组织受照剂量，减轻放射治疗对正常组织的伤害，在放射增敏方面有重要作用，本文从纳米金的基本特性、生物学毒性、放射增敏机制、在细胞和动物模型中增敏实验以及在临床前应用等几方面进行综述。
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| 关 键 词： | 纳米金 放射增敏 肿瘤 靶向 |
| 收稿时间： | 2014-07-04 |
Basic Characteristics of Gold Nanoparticles and Its Effect on Tumor Radiosensitization |
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| ZHU Chuandong,WANG Lixue,ZHENG Qin,WU Jianqing. Basic Characteristics of Gold Nanoparticles and Its Effect on Tumor Radiosensitization[J]. Cancer Research on Prevention and Treatment, 2015, 42(7): 720-724. DOI: 10.3971/j.issn.1000-8578.2015.07.017 |
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| Authors: | ZHU Chuandong WANG Lixue ZHENG Qin WU Jianqing |
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| Affiliation: | 1. Department of Oncology, The Second Affiliated Hospital of Southeast University, Nanjing 210003, China; 2. Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China |
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| Abstract: | With its unique physical and chemical properties, gold nanoparticles receive more and more attention in the medical field. In recent years, many studies have confirmed that gold nanoparticles play an important role in radiosensitization. It can reduce tissue radiation dose and lower the radiation damage to normal tissues in cancer therapy. This paper will review the basic characteristics of gold nanoparticles, biological toxicity, radiosensitization mechanisms, radiosensitization experiments in cells and animal models, and preclinical applications. |
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| Keywords: | Gold nanoparticles Radiosensitization Tumor Target |
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