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超敏C反应蛋白和补体C3与系统性红斑狼疮疾病活动度的关系
引用本文:李晓洁,周 蕾,陈 宪,王颖嫒.超敏C反应蛋白和补体C3与系统性红斑狼疮疾病活动度的关系[J].天津医科大学学报,2015,0(3):63-64.
作者姓名:李晓洁  周 蕾  陈 宪  王颖嫒
作者单位:(天津医科大学总医院风湿免疫科 ,天津 300052)
摘    要:

关 键 词:红斑狼疮  系统性  超敏C反应蛋白  补体C3  疾病活动度

Relationship between  high-sensitivity C-reactive and complement 3 and disease activity in systemic lupus erythematosus
LI Xiao-jie,ZHOU Lei,CHEN Xian,WANG Ying-ai.Relationship between  high-sensitivity C-reactive and complement 3 and disease activity in systemic lupus erythematosus[J].Journal of Tianjin Medical University,2015,0(3):63-64.
Authors:LI Xiao-jie  ZHOU Lei  CHEN Xian  WANG Ying-ai
Institution:(Department of Rheumatology and Immunology ,Tianjin Medical University ,General Hospital ,Tianjin 300052 ,China)
Abstract:Objective : To explore the relationship between the levels of high-sensitivity C-reactive protein(hsCRP),complement3(C3) and disease activity in patients with systemic lupus erythematosus(SLE).Methods : A total of 101 patients with SLEwere divided into two groups in accordance with SLEDAI scores, the active group(n=28)and the remission group(n=73).Plasma was assayed for hsCRP by immunological transmission turbidimetry,and serum was assayed for C3 by radiation rate nephelometry. All data were analyzed by Students’t test, Chi-squared test and Pearson regression analysis.Results: Patients in active group had higher hsCRP levels than patients in remisson group(9.03±6.84)mg/L ] vs (1.51±1.27)mg/L],and patients in active group had lower C3 levels than patients in remisson group(677.00±389.75)mg/L] vs(877.94±316.54)mg/L] differences were statistically significant(P<0.05);hsCRP levels were positively correlated with SLEDAI score(r=0.649,P<0.01),complement3 levels and SLEDAI score were negatively correlated(r=-0.590,P<0.01).Conclusion : HsCRP and C3 are closely related with SLE activity and can be used as one of the indicators for SLE activity and the clinical result.
Keywords:lupus erythematosus  systemic  high-sensitivity C-reactive protein  complement 3  disease activity
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