三阴与非三阴乳腺癌的临床病理特征及Ki-67 表达的对比研究

目的探讨三阴与非三阴乳腺癌的临床病理特征及Ki-67 表达的差异。方法采用免疫组化Envision 二步法检测226 例乳腺癌患者雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（HER2）的表达，根据三者表达情况分为三阴组（n=41）和非三阴组（n=185），并采用免疫组化方法检测并比较2 组组织中Ki-67 阳性指数差异，以及2 组不同临床病理特征分层Ki-67 阳性指数差异。结果三阴组肿瘤大小及淋巴结转移率、Ki-67 阳性指数均高于非三阴组（P < 0.05），2 组不同的年龄、肿瘤大小、淋巴结状况及组织学分级的Ki-67 表达差异均无统计学意义（P > 0.05）。结论与非三阴乳腺癌比较，三阴乳腺癌的肿瘤体积更大、瘤细胞增殖活性更高、更易发生淋巴结转移，预后更差。

Comparison of clinical-pathological features and Ki-67 expression profile between triple-negative breast cancer (TNBC) and non-triple-negative cancer

Objective To compare clinical-pathological features and Ki-67 expression profile between TNBC and Non-triple-negative cancer (NTNBC). Methods The expressions of ER, PR and HER2 were examined by immunohisto? chemical Envision double staining in 226 cases of breast cancer. All cases were divided into triple-negative and non-triplenegative group according to expressions of these three episodes. And Ki-67 expressions in two groups were assessed by im? munohistochemical method. The difference of Ki-67 positive index between these two groups and the difference of Ki-67 positive index between different clinical-pathological features were both analyzed by comparative analysis. Results In pa? tients with TNBC, tumor size, lymph node metastasis rate and Ki-67 index were all significantly higher than that in NTNBC. No significant difference in age and histological grade were detected between these two groups. The expression of Ki-67 was not significant correlated with age, tumor size，lymph node status and histological grade in these two groups. Conclusion Patients with triple-negative breast cancer were with larger tumor size, higher proliferation, more lymph node metastasis and poorer prognosis.