Galectin-3 和β-catenin 在子宫内膜异位症中的表达及二者的相关性

目的探讨半乳糖凝集素-3（Galectin-3）和β连环素（β-catenin）在子宫内膜异位症（EMs）患者的异位内膜和在位内膜中的表达及其在EMs 发病中的作用及关系。方法应用免疫组织化学法检测34 例EMs 患者（EMs 组）的异位内膜和在位内膜及30 例非子宫内膜异位症（正常对照组）的在位子宫内膜中的半乳糖凝集素-3 和β连环素的表达情况，并分析二者的相关性。结果半乳糖凝集素-3 在EMs 组异位内膜、在位内膜及正常对照组在位内膜的阳性表达率分别为88.2%、85.3%、50.0%；β连环素在上述3 组的异常表达率分别为55.9%、52.9%、26.7%。EMs 异位内膜组、在位内膜组的半乳糖凝集素-3 的阳性表达率和β连环素的异常表达率均高于正常对照组（P＜0.05）。EMs 组异位内膜、在位内膜中的半乳糖凝集素-3 的阳性表达和β连环素的异常表达呈正相关（rs 分别为0.512、0.428，P＜ 0.01）。结论半乳糖凝集素-3 和β连环素可能在EMs 的发病中共同起着重要作用。

The expressions of Galectin-3 and β-catenin and their correlation studies in endometriosis

Objective To investigate the expressions and mutual relationship of Galectin-3 and β-catenin in endome⁃ triosis (EM). Methods Immunohistochemistry was used to detect expression levels of Galectin-3 and β-catenin and their mutual relationship in expression was also examined. Samples were collected from ectopic endometrium of patients with en⁃ dometriosis (ectopic endometrium group, n=34), eutopic endometrium of patients with endometriosis (eutopic endometrium group, n=34) and normal endometrium from people without endometriosis (control group, n=30). Results The expressions of Galectin-3 were seen in 88.2%, 85.3%, 50.0% of cases in ectopic endometrium group, eutopic endometrium group and control group respectively. On the other hand, the expression of β-catenin were seen in 55.9%, 52.9%, 26.7% of cases in ecto⁃ pic endometrium group, eutopic endometrium group and control group respectively. In EMs patients, the expression of Galec⁃ tin-3 and β-catenin were significantly higher in ectopic endometrium and eutopic endometrium than those in normal endome⁃ trium group（P＜0.05）. Expression of Galectin-3 was positive correlated with expression of β-catenin（rs=0.512, 0.428, P＜ 0.01）. Conclusion Galectin-3 and β-catenin may play important roles synergistically in the pathogenesis of endometriosis.