| 卵巢癌患者血液高凝状态临床研究进展 |
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| 引用本文： | 冯征,温灏,吴小华.卵巢癌患者血液高凝状态临床研究进展[J].中国癌症杂志,2015,25(3):231-234. |
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| 作者姓名： | 冯征 温灏 吴小华 |
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| 作者单位： | 复旦大学附属肿瘤医院妇瘤科，复旦大学上海医学院肿瘤学系，上海200032 |
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| 基金项目： | 上海市科学技术委员会重点项目(12411950300)。 |
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| 摘 要： | 卵巢癌患者的静脉血栓发生率远高于其他妇科肿瘤，约20%以上的卵巢癌患者存在高凝状态。肿瘤可导致血液高凝状态，而凝血功能的过度激活也极大地促进肿瘤的进展，是影响患者预后的重要因素。近年来，高凝状态逐渐成为卵巢癌研究领域的新热点，本文将对卵巢癌患者高凝状态的形成机制、临床意义及相关治疗进展进行综述。
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| 关 键 词： | 卵巢癌 高凝状态 白细胞介素-6 |
Clinical advancement of hypercoagulability in patients with ovarian cancer |
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| FENG Zheng,WEN Hao,WU Xiaohua.Clinical advancement of hypercoagulability in patients with ovarian cancer[J].China Oncology,2015,25(3):231-234. |
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| Authors: | FENG Zheng WEN Hao WU Xiaohua |
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| Institution: | Department of Gynecological Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China |
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| Abstract: | The incidence of venous thromboembolism in patients with ovarian cancer is much higher than other gynecologic cancers. Approximate 20% of ovarian cancer patients have hypercoagulable status during different phases of their disease. Ovarian cancer itself can induce hypercoagulability, but meanwhile the over activated coagulation system may promote disease progression. Coagulation system disorder is one of the most important prognostic factors in ovarian cancer. Recently, hypercoagulability becomes a hot spot in the ovarian cancer research field. This article reviews the mechanism of hypercoagulability, its clinical implication and correlated treatment in ovarian cancer patients. |
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| Keywords: | Ovarian cancer Hypercoagulability Interleukin-6 |
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