单发2cm以下微血管侵犯肝癌患者的预后生存分析

目的 2 cm以下的单发肝癌有着良好的术后生存。而微血管侵犯被认为是影响肝癌预后的独立危险因素，其对单发小肝癌（≤2 cm）的影响尚不清楚。本研究的目的在于研究微血管侵犯对于2 cm以下单发肝癌预后的影响。方法 回顾性分析云南省肿瘤医院2001年1月至2008年12月间住院的62例2 cm以下单发肝癌患者的临床及术后病理资料，探讨微血管侵犯对预后的影响。结果 62例2cm以下单发肝癌患者中，16例有微血管侵犯、46例无微血管侵犯。16例有微血管侵犯的患者，其术后5年生存率为81.3%，而无微血管侵犯患者的术后5年生存率为93.5%，两者之间差异无统计学意义（P=0.496）。结论 2 cm以下的单发肝癌有着良好的预后，微血管侵犯不影响2 cm以下单发肝癌的长期生存；为了确认微血管侵犯是否不影响2 cm以下单发肝癌的长期生存，仍需要多中心大样本的数据进行进一步验证。

Long-term Survival of Single Hepatocellular Carcinoma ≤2cm with Microvascular Invasion

Objective Excellent long-term outcomes have been reported recently for patients with singlehepatocellular carcinoma(HCC) ≤2cm. However, how microvascular invasion(MVI), as an independent riskfactor for HCC, affects small single HCC remains unclear. The purpose of this paper is to determine the impactof MVI on the prognosis of single HCC ≤2cm. Methods We retrospectively reviewed clinicopathologicaldata of 62 patients with HCC ≤ 2cm, hospitalized from January 2001 to December 2008 in Yunnan ProvincialCancer Hospital. Results Among 62 patients, the 5-year overall survival(OS) rate of 16 patients with MVIwas 81.3%, while that of 46 patients without MVI was 93.5% (P=0.496). Conclusion Patients with singleHCC ≤2cm have excellent prognosis, and MVI has no influence on the 5-years overall survival rate; whileit still needs further validation by multi-centers’ and large sample size investigation to confirm if MVI affectsthe long-term survival or not.