| 大孔吸附树脂吸附纯化甘草酸的工艺研究 |
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| 引用本文： | 王亚红,周端文. 大孔吸附树脂吸附纯化甘草酸的工艺研究[J]. 中成药, 2006, 28(9): 1268-1271 |
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| 作者姓名： | 王亚红 周端文 |
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| 作者单位： | 吉林化工学院,制药与应用化学系,吉林,吉林,132022 |
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| 基金项目： | 吉林化工学院院内项目,名称:甘草酸提取与精制新工艺研究编号:吉化院合字第0453-11号 |
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| 摘 要： | 目的:研究D-101型大孔吸附树脂吸附纯化甘草酸的工艺条件。方法:通过正交实验方法优化工艺条件以香草醛-硫酸比色法测定甘草酸含量。结果:优化的工艺条件为:纯化用4倍树脂柱体积10乙醇最经济;吸附和洗脱流速均为2mL/min:原液pH值为5.8;原液浓度为9mg/mL(甘草酸粗品/体积)。结论:D-101型大孔吸附树脂对甘草酸有良好的吸附纯化性能,易于洗脱,分离效果好,产品纯度可达95.109。
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| 关 键 词： | 甘草酸 D-101型大孔吸附树脂 纯化 |
| 文章编号： | 1001-1528（2006）09-1268-04 |
| 收稿时间： | 2005-12-15 |
| 修稿时间： | 2005-12-15 |
Absorption and purification of glycyrrhizic acid with macro resin |
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| WANG Ya-hong,ZHOU Duan-wen. Absorption and purification of glycyrrhizic acid with macro resin[J]. Chinese Traditional Patent Medicine, 2006, 28(9): 1268-1271 |
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| Authors: | WANG Ya-hong ZHOU Duan-wen |
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| Affiliation: | Dept. of Pharmacy and Applied Chemistry, Jilin College of Chemical Technology, Jilin 132022, China |
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| Abstract: | AIM: An optimal method for purifying glycyrrhizic acid with D-101 macro resin was developed. METHODS: The contents of glycyrrhizic acid were used as the evaluating criteria, by means of vanlillin-sulfuric acid colorimetry. RESULTS: The optimum technical operations were as follows: 10% ethanol(4 times the volume of the resin) was used to elute glycyrrhizic acid; both the current velocity of absoring and eluting were 2 mLmin, pH of the sample was 5.8 , concentration of the sample was 9 mgmL (weight of the raw materialvolume). CONCLUSION: The results show that D-101 macro resin is suitable for absorbing and purifying glycyrrhizic acid. |
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| Keywords: | glycyrrhizic acid D-101 macro resin purification |
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