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大孔吸附树脂吸附纯化甘草酸的工艺研究
引用本文:王亚红,周端文. 大孔吸附树脂吸附纯化甘草酸的工艺研究[J]. 中成药, 2006, 28(9): 1268-1271
作者姓名:王亚红  周端文
作者单位:吉林化工学院,制药与应用化学系,吉林,吉林,132022
基金项目:吉林化工学院院内项目,名称:甘草酸提取与精制新工艺研究编号:吉化院合字第0453-11号
摘    要:目的:研究D-101型大孔吸附树脂吸附纯化甘草酸的工艺条件。方法:通过正交实验方法优化工艺条件以香草醛-硫酸比色法测定甘草酸含量。结果:优化的工艺条件为:纯化用4倍树脂柱体积10乙醇最经济;吸附和洗脱流速均为2mL/min:原液pH值为5.8;原液浓度为9mg/mL(甘草酸粗品/体积)。结论:D-101型大孔吸附树脂对甘草酸有良好的吸附纯化性能,易于洗脱,分离效果好,产品纯度可达95.109。

关 键 词:甘草酸  D-101型大孔吸附树脂  纯化
文章编号:1001-1528(2006)09-1268-04
收稿时间:2005-12-15
修稿时间:2005-12-15

Absorption and purification of glycyrrhizic acid with macro resin
WANG Ya-hong,ZHOU Duan-wen. Absorption and purification of glycyrrhizic acid with macro resin[J]. Chinese Traditional Patent Medicine, 2006, 28(9): 1268-1271
Authors:WANG Ya-hong  ZHOU Duan-wen
Affiliation:Dept. of Pharmacy and Applied Chemistry, Jilin College of Chemical Technology, Jilin 132022, China
Abstract:AIM: An optimal method for purifying glycyrrhizic acid with D-101 macro resin was developed. METHODS: The contents of glycyrrhizic acid were used as the evaluating criteria, by means of vanlillin-sulfuric acid colorimetry. RESULTS: The optimum technical operations were as follows: 10% ethanol(4 times the volume of the resin) was used to elute glycyrrhizic acid; both the current velocity of absoring and eluting were 2 mLmin, pH of the sample was 5.8 , concentration of the sample was 9 mgmL (weight of the raw materialvolume). CONCLUSION: The results show that D-101 macro resin is suitable for absorbing and purifying glycyrrhizic acid.
Keywords:glycyrrhizic acid  D-101 macro resin  purification
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