| TLR接头蛋白研究进展 |
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| 引用本文： | 董秋萍,李涛,熊自忠.TLR接头蛋白研究进展[J].基础医学与临床,2011,31(1):97-100. |
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| 作者姓名： | 董秋萍 李涛 熊自忠 |
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| 作者单位： | 1. 安徽医科大学,第一附属医院感染病科,安徽合肥,230022
2. 安徽医科大学,第一附属医院检验科,安徽合肥,230022 |
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| 基金项目： | 国家自然基金(30801088); 安徽省卫生厅临床医学应用技术项目(2008A022); 安徽省高校自然科研基金(KJ2009B078); 教育部科学技术研究重点项目(209059); 安徽省优秀青年科技基金(08040106815); 安徽省人事厅基金(2008-25); 卫生厅人才基金(2009332) |
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| 摘 要： | Toll样受体(TLR)是近年来备受关注的一类病原体识别受体,能选择性地识别侵入机体的病原微生物所携带的病原相关分子模式(PAMPs),继而激活信号级联放大,产生免疫应答.目前研究发现,TLR识别相应配体后,由一类包含TLR结构域的接头蛋白MYD88、MAL、TRIF、TRAM和SARM通过MYD88依赖途径或MYD8...
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| 关 键 词： | TLR TIR 接头蛋白 信号传导 |
Toll-like receptor adaptor proteins |
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| DONG Qiu-ping,LI Tao,XIONG Zi-zhong.Toll-like receptor adaptor proteins[J].Basic Medical Sciences and Clinics,2011,31(1):97-100. |
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| Authors: | DONG Qiu-ping LI Tao XIONG Zi-zhong |
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| Institution: | DONG Qiu-ping1,LI Tao2,XIONG Zi-zhong1(1.Dept.of Infection Disease,2.Clinical Laboratory,the First Affiliated Hospital,Anhui Medical University,Hefei 230022,China) |
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| Abstract: | Toll-like receptor(TLR) is a pathogen recognition receptor and is the item of research in recent years.It discriminates different pathogen-associated molecular patterns(PAMPs) and activates signaling cascades leading to immune responses.The specific TLR signal is conducted by adaptor proteins containing toll-interleukin1 receptor(TIR) domains.The function is carried out by MYD88 or no-MYD88/TRIF pathway involving five TIR adaptors: MYD88,MAL,TRIF,TRAM and SARM. |
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| Keywords: | TLR TIR adaptor protein signal transduction |
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