新疆地区维吾尔族乳腺癌患者SATB1表达与临床病理特征的关系

目的 探讨维吾尔族乳腺癌患者组织中特异AT序列结合蛋白1（SATB1）的表达及其与临床病理特征的关系。方法 选择2014年1月至2015年1月新疆医科大学附属肿瘤医院收治的维吾尔族乳腺癌患者158例，其中原位癌26例，浸润性癌132例。采用免疫组化SP法检测乳腺癌组织中SATB1表达，并分析其表达与乳腺癌临床病理特征的关系。结果 SATB1在癌旁组织中的阳性表达率为8.0％（4／50），原位癌组织中为42.3％（11／26），浸润性癌组织中为70.5％（93／132），差异有统计学意义（P＜0.05）。SATB1表达与乳腺浸润癌患者的原发肿瘤大小、淋巴结转移、TNM分期及组织学分级均有关（P＜0.05），而与年龄、绝经情况、病理分型、激素受体及HER-2表达均无关 （P＞0.05）。结论 SATB1表达可能与维吾尔族乳腺癌的发生发展有关。

Expression of SATB1 in Xinjiang Uygur patients with breast cancer and its relationship with clinicopathological features

Objective To detect the special AT rich sequence binding protein（SATB1） expression in Uygur patients with breast cancer，and explore its relationship with clinicopathologic characteristics. Methods One hundred and fifty eight Uygur patients with breast cancer from Jan. 2014 to Jan. 2015 in Xinjiang Tumor Hospital were enrolled， including 26 cases of carcinoma in situ and 132 cases of invasive carcinoma. SATB1 expression in cancer tissues were detected by immunohistochemistry method, and the relationship between SATB1 expression and clinicopathologic characteristics was analyzed. Results The positive expression rate of SATB1 in para carcinoma tissues was 8.0％（4／50）， in carcinoma in situ tissues was 42.3％（11／26）， and in invasive carcinoma tissues was 70.5％（93／132）. The difference was statistically significant （P＜0.05）. In breast invasive carcinoma patients， SATB1 expression was related with primary tumor size， lymph node metastasis, TNM staging and histological grade（P＜0.05）， but not related with the age， menopausal status， pathological types， hormone receptors and HER 2 expression （P＞0.05）. Conclusion SATB1 expression in breast cancer tissue of Uygur patients can be influential in the occurence and development of breast cancer.