Inflammation and Arterothrombosis

Arterial thrombosis is a central pathologic mechanism contributing to myocardial infarction and stroke, together the leading causes of death in China and developed countries. The basic pathologic change is atherosclerosis, the earliest visible lesion of atherosclersis is the fatty streak, which is due to an accumulation of lipidladen foam cells in the intimal layer of the artery. With time , the fatty streak evolves into a fibrous plaque. The pathogenesis of atherosclerosis has been considered a disorder due to abnormalities in lipid metabolism for long time. In fact, the inciting event of atherosclerosis is likely an inflammatory insult that occurs decades before the disease becomes clinically apparent. The atherosclerotic process is characterized in its earliest stages, by perturbation in endothelial function. Atherosclerosis is likely initiated when endothelial cells overexpress adhesion molecules in response to turbulent flow in the setting of an unfavorable serum lipid profile. The overexpress vascular cell adhesion molecule-1 （ VCAM- 1 ） on endothelial surfaces was an early, and necessary, step in the pathogenesis of atherosclerosis.

Inflammation and Arterothrombosis

Inflammation Arterothrombosis