Effects of scopolamine and physostigmine on recognition memory in monkeys with ibotenic-acid lesions of the nucleus basalis of Meynert |
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| Authors: | T. G. Aigner S. J. Mitchell J. P. Aggleton M. R. DeLong R. G. Struble D. L. Price G. L. Wenk M. Mishkin |
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| Affiliation: | (1) Laboratory of Neuropsychology, National Institute of Mental Health, 9000 Rockville Pike, 20892 Bethesda, MD, USA;(2) Departments of Neurology and Neuroscience, John Hopkins University, School of Medicine, 21205 Baltimore, MD, USA;(3) Department of Pathology, John Hopkins University, School of Medicine, 21205 Baltimore, MD, USA;(4) Departments of Pathology, Neurology, and Neuroscience, Neuropathology Laboratory, John Hopkins University, School of Medicine, 21205 Baltimore, MD, USA;(5) Department of Psychology, Johns Hopkins University, 21218 Baltimore, MD, USA;(6) Present address: Department of Psychology, Science Laboratories, University of Durham, South Road, DH1 3LE Durham, England |
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| Abstract: | Monkeys with bilateral ibotenic-acid lesions of the nucleus basalis of Meynert, an area rich in cholinergic neurons that innervate the cerebral cortex, were compared with unoperated control monkeys on a recognition memory task. Although animals with large lesions had substantial reductions of cortical choline acetyltransferase activity, none showed impairment in the task. Lesion effects were observed, however, when performance was assessed following administration of a muscarinic receptor blocker (scopolamine) or a cholinesterase inhibitor (physostigmine). Although scopolamine produced dose-related impairments in both groups, this effect was greater in the experimental animals. Conversely, whereas physostigmine produced modest improvement in performance in the control group, no such improvement was observed in the experimental animals. The altered sensitivity to the mnemonic effects of cholinergic agents in the experimental group suggests that the cholinergic neurons of the nucleus basalis of Meynert contribute to recognition memory. |
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| Keywords: | Cholinergic system Drug effects Ibotenic acid Memory Monkeys Nucleus basalis of Meynert |
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