慢性乙型肝炎患者乙型肝炎病毒前C区基因突变与临床关系

为了解慢性乙型肝炎患者是否有前Ｃ区基因突变及其与临床的关系，应用快速检测乙型肝炎病毒前Ｃ区基因突变方法，对５３例患者进行了研究。结果显示：２５例ＨＢＶＤＮＡ阳性患者中１３例有突变株感染，最常见的突变形式为１８９８位或伴有１９０１位突变（１０／１３例）。

Studies of HBV precore mutation in patients with type B chronic hepatitis

To examine whether there are precore mutants in patients with type B chronic hep-atitis and its clinicai relevance,we used rapid detection method for hepatitis B virus(HBV)precoremutation in 53 patients.The results showed that of 25 HBV DNA positive patients,13 patientswere infected by mutants or coinfected by precore mutants and wild type strain,The mutation at nt1898 or/and nt 1901 was the most common mutation(10/13).It was found that there were no cor-relation between infection with precore mutants and sex,age,family history of HBV infection,andserum level of ALT,Patients with clinical course>5 years had an increasing detection rate of pre-core mutants.Precore mutants were mainly found in anti-HBe positive patients(77.8%).Therewas a higher detection rate of precore mutants in patients with severe hepatitis(66.7%),andseemed associated with the severity of liver inflammationThe results suggest that the occurrence ofprecore mutants may be associated with immune selective pressure in the infected host.