| ERCC1对晚期非小细胞肺癌一线含铂化疗疗效的预测价值 |
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| 引用本文： | 宁晓红,王毓洲,孙昭,李霁,周艳萍,白春梅.ERCC1对晚期非小细胞肺癌一线含铂化疗疗效的预测价值[J].协和医学杂志,2010,1(2):155-159. |
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| 作者姓名： | 宁晓红 王毓洲 孙昭 李霁 周艳萍 白春梅 |
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| 作者单位： | 1.中国医学科学院 北京协和医学院 北京协和医院 肿瘤内科, 北京 100730 |
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| 摘 要： | 目的 探讨肺癌组织ERCC1(excision repair cross-complementation group1)表达水平对晚期非小细胞肺癌含铂化疗疗效及生存期的预测价值。 方法 采用免疫组织化学方法对39例非小细胞肺癌患者的石蜡包埋肿瘤标本进行ERCC1检测, 分析其与化疗反应率及生存期间的关系。 结果 56.4%(22/39)的肿瘤组织呈ERCC1高表达。ERCC1表达与患者性别、年龄、病理类型、肿瘤分化程度、吸烟史及吸烟指数均无相关性; ERCC1低表达患者对含铂一线化疗的反应率优于ERCC1高表达者, P < 0.05。但ERCC1表达水平对患者总生存(overall survival, OS)和疾病进展(time to progression, TTP)时间没有明显影响。 结论 ERCC1在肺癌组织的表达水平可能成为预测晚期非小细胞肺癌患者一线含铂化疗方案疗效的因素之一。
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| 关 键 词： | ERCC1 非小细胞肺癌 化疗 免疫组织化学 |
| 收稿时间： | 2010-08-23 |
Role of ERCC1 Expression in Predicting the Outcome of Platinum-based Chemotherapy in Patients with End-stage Non-small-cell Lung Cancer |
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| Authors: | NING Xiao-hong WANG Yu-zhou SUN Zhao LI Ji ZHOU Yan-ping BAI Chun-mei |
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| Institution: | 1.Department of Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China2.Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China |
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| Abstract: | Objective To explore the role of expression of excision repair cross-complementation group 1 (ERCC1) in predicting the outcomes of platinum-based chemotherapy in patients with end-stage non-small-cell lung cancer. Methods The expression of ERCC1 was detected with immunohistochemical methods in paraffin-embeded tumor specimens obtained from 39 patients with chemo-naive non-small-cell lung cancer. The relationship between ERCC1 expression and the response rate of platinum-based chemotherapy as well as its pos... |
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| Keywords: | excision repair cross-complementation group 1 non-small cell lung cancer chemotherapy immunohistoche-mistry |
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