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Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors |
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| Authors: | Takeru Ehara Osamu Irie Takatoshi Kosaka Takanori Kanazawa Werner Breitenstein Philipp Grosche Nils Ostermann Masaki Suzuki Shimpei Kawakami Kazuhide Konishi Yuko Hitomi Atsushi Toyao Hiroki Gunji Frederic Cumin Nikolaus Schiering Trixie Wagner Dean F. Rigel Randy L. Webb Jürgen Maibaum Fumiaki Yokokawa | |
| Affiliation: | †NovartisInstitutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan;‡NovartisInstitutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland;∥Novartis Pharmaceuticals Corp., Institutes for BioMedical Research, East Hanover, New Jersey 07936, United States | |
| Abstract: | ||
| Keywords: | Renin inhibitor structure-based design asparticprotease 3 5-piperidines | |