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Breakthrough Invasive Candida glabrata in Patients on Micafungin: a Novel FKS Gene Conversion Correlated with Sequential Elevation of MIC |
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| Authors: | Takeshi Saraya Koichi Tanabe Koji Araki Shota Yonetani Hiroshi Makino Takayasu Watanabe Naoki Tsujimoto Saori Takata Daisuke Kurai Haruyuki Ishii Yoshitsugu Miyazaki Hajime Takizawa Hajime Goto |
| Institution: | aKyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan;bDepartment of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan;cKyorin University School of Medicine, Department of Laboratory Medicine, Mitaka, Tokyo, Japan |
| Abstract: | Candida glabrata strains sequentially isolated from blood developed resistance to micafungin (MICs from <0.015 to 4 μg/ml). A novel mutation identified in micafungin-resistant strains at bp 262 of FKS2 (containing a deletion of F659 F659del]) was inserted into the homologous region in FKS1. |
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