食管鳞癌DNA含量与临床病理及预后的关系

应用自动化图像分析仪对５０例食管鳞癌进行细胞ＤＮＡ定量分析，结合临床资料，发现肿瘤分化越差、外侵越严重，ＤＮＡ含量越高。淋巴结转移组ＤＮＡ含量高于非转移组。二倍体或近二倍体组１、３、５年生存率明显高于异倍体组（Ｐ＜０．０１）。表明ＤＮＡ含量的测定可从核酸代谢的分子水平揭示食管癌恶性生物学行为，同时可作为估计手术预后的客观定量指标。

DNA Content and Its Relationship to Clinico-Pathological Feature and Prognosis in Esophageal Squamous Cell Carcinoma

DNA content in surgical samples from 50 patients with esophageal squamous cell carcinoma was determined by automatic image analysis technology. The result showed that the DNA index (DI) correlated significantly with both histologic grading(P <0. 01) and the extent of wall penetration by the tumor (P<0. 05).DI in the group with lymph node metastases is higher than that in the group without lymph node metastasis, but there was no statistic significance.(P>0. 05). The 1 year,3 year and 5 year survival rate of the diploidy patients with squamous cell carcinoma was markedly higher than those of the aneuploidy patients with same kind of tumors respectively.The determination of the content of DNA in esophageal squamous cell carcinoma can explore the malignant biological behavior of the carcinomatous squamous cells through the changes of the metabolism of the neucleic acid at the molecular level.Therefore,the tumor DNA content is an important prognostic variable.