不用体外循环的异位并列心脏移植实验研究

１９８８年７月至１９９１年７月，我们在不用体外循环情况下做了７０条犬胸内异位并列心脏移植实验。术后供心总复跳率９１．４２％，犬最长存活１３天。供心植入２８ｈ后，以多普勒相控阵超声显象诊断仪检查，可见自体心与供心功能均正常。８ｋｇ重犬的供心植入后，每分钟排血１．２Ｌ，左室收缩增厚率２０％。移植后存活１３天的供心组织学检查见有明显急性排斥反应改变。

Experimental Study of Heterotopic Heart Transplantation without Cardiopulmonary Bypass

From 1988 to 1991,70 heterotopic heart transplantions (HHT) on canines were performed under normothermia with endotracheal anesthesia but without cardiopulmonary bypass.The total recovery rate of donor heart-beat after transplantation was 91. 42%.The longest survival time after HHT. was 13 days.M-mode echocardiography revealed good function of both recipient's and transplanted hearts.The cardiac output (CO) of donor's heart from canine weighing 8kg was 1. 2 L/min and the thickening rate of left ventricular wall during contraction was 20%. In the meantime, the phased array ultrasonic imaging system echocardiography showed normal beart beat of the transplanted hearts as well as the recipient's hearts with good mitral and tricuspid valvular function.The pathologic change of donor heart after survival for 13 days showed evidence of acute rejection.