HEPATIC AND EXTRAHEPATIC DISPOSITION OF PROPOFOL IN PATIENTS UNDERGOING CORONARY BYPASS SURGERY期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

HEPATIC AND EXTRAHEPATIC DISPOSITION OF PROPOFOL IN PATIENTS UNDERGOING CORONARY BYPASS SURGERY

Authors:	LANGE, H. STEPHAN, H. RIEKE, H. KELLERMANN, M. SONNTAG, H. BIRCHER, J.

Affiliation:	¹Department of Clinical Anaesthesiology, University of Gottingen Robert Koch Str. 40, 3400 G $"o"$ ttingen, F.R.G. ²Department of Clinical Pharmacology, University of G $"o"$ ottingen Robert Koch Str. 40, 3400 G $"o"$ ttingen, F.R.G.

Abstract:	In order to clarify the relative contribution of the liver tothe short term disposition of propofol, hepatic blood flow wasmeasured during induction of anaesthesia with an i.v. bolusdose of propofol 2 mg kg¹. Total clearance of the drugwas 2390 (SD 340) ml min¹, hepatic extraction 82% andhepatic clearance 1060 (260) ml min¹. During the 60-minperiod of observation, hepatic extraction of propofol increasedfrom 79% to 92%. It is concluded that, within 1 h, only 44%of the administered dose is removed by the liver. Consequently,drug accumulation may occur with repeated dosing or infusionof propofol. The increase in extraction results presumably fromslow release of propofol from the soy-bean emulsion. Results presented in part at the 29th Spring Meeting of theGerman Association of Pharmacology, March 811, Mainz,FRG. (Abstract (No. 490) in Naunyn-Schmiedebergs Archives ofPharmacology 1988; 337 (Suppl.): R123.)

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