| 钌红对豚鼠离体心室肌细胞钙激活电流的影响 |
| |
| 引用本文： | 崔毅,谭月华.钌红对豚鼠离体心室肌细胞钙激活电流的影响[J].中国药理学与毒理学杂志,1993,7(3):235-236. |
| |
| 作者姓名： | 崔毅 谭月华 |
| |
| 作者单位： | 第四军医大学药理教研室，第四军医大学药理教研室 西安 710032，西安 710032 |
| |
| 摘 要： | <正> 钌红(ruthenium red,RR)是电镜研究中常用的一种组织染料。近来发现RR具有抑制线粒体钙摄取和肌质网钙释放等作用。但RR对心肌细胞内Ca~(2+)浓度的影响目前尚未见报道。本文通过观察RR对豚鼠离体心室肌细胞钙激活电流的影响,对这一问题作一探讨。
|
| 关 键 词： | 钌红 心肌细胞 钙激活电流 |
Effects of ruthenium red on Ca~(2+)-activated current in isolated guinea pig ventricular myocytes |
| |
| CUI Yi,TAN Yue-Hua.Effects of ruthenium red on Ca~(2+)-activated current in isolated guinea pig ventricular myocytes[J].Chinese Journal of Pharmacology and Toxicology,1993,7(3):235-236. |
| |
| Authors: | CUI Yi TAN Yue-Hua |
| |
| Abstract: | Effects of ruthenium red(RR)on Ca2+] in isolated guinea pig ventricular myocytes were investigated using Ca2+-activated current as an indicator of changes in Ca2+] Action potentials were interrupted by the application of a 300 ms voltage clamp to 40 mV in order to elicit the Ca2+-activated current.Exposure to 2.5*****umol·L-1 RR resulted in an increase in Ca2+ activated current without changingaction potentials.RR appeared not to modify the time course of the envelope of currents.The results indicate that RR could increase Ca2+] in guinea pig ventricular myocytes. |
| |
| Keywords: | Ruthenium red Cardiac cells Ca~(2+) activated current |
| 本文献已被 CNKI 维普 等数据库收录！ |
