Churg-Strauss syndrome |
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Authors: | Zwerina J |
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Institution: | Medizinische Klinik 3 mit Rheumatologie und Klinischer Immunologie, Universit?t Erlangen-Nürnberg, Erlangen, Deutschland. jochen.zwerina@uk-erlangen.de |
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Abstract: | Churg-Strauss syndrome is a systemic ANCA-associated vasculitis arising almost exclusively in patients with a pre-existent asthma. Common clinical manifestations are marked blood eosinophilia, asthma, chronic sinusitis, cardiomyopathy, pulmonary infiltrates, gastrointestinal complaints and a multiplex neuropathy. The morphological substrate is an eosinophilic necrotizing vasculitis.Other eosinophilic disorders such as parasitic diseases, allergies and idiopathic hyper-eosinophilic syndrome have to be excluded. The mainstay of therapy is high-dose corticosteroids with the addition of cytotoxic drugs in patients with poor prognosis. |
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