| CpG ODN刺激PBMC后作用于卵巢癌细胞HO8910杀伤活性的研究 |
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| 引用本文： | 吴富菊,马晓艳,魏敏,薛惠荣. CpG ODN刺激PBMC后作用于卵巢癌细胞HO8910杀伤活性的研究[J]. 中国实验诊断学, 2007, 11(2): 163-165 |
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| 作者姓名： | 吴富菊 马晓艳 魏敏 薛惠荣 |
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| 作者单位： | 1. 吉林大学第二医院,妇产科,吉林,长春,130041
2. 解放军222医院 |
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| 摘 要： | 目的探讨合成含CpC基序的寡核苷酸（CpG ODN）在肿瘤免疫治疗中的研究。方法将CpG ODN刺激体外培养的人外周血单个核细胞（PBMC）后作用于卵巢癌细胞株（H198910），采用MTT法检测其杀伤活性。结果加CpG ODN组较单独PBMC组杀伤活性明显增高（P＜0．05）。结论CpG ODN可刺激PBMC增殖，提高PBMC的杀伤活性，从而增强机体的特异性和非特异性免疫效应。
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| 关 键 词： | 卵巢癌细胞株(HO8910) MTT法 |
| 文章编号： | 1007-4287（2007）02-0163-03 |
| 收稿时间： | 2006-07-15 |
| 修稿时间： | 2006-07-15 |
The study of Killing activity of PBMC stimulated by CpG ODN on HO8910 |
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| WU Fu-ju,MA Xiao-yan, WEI Min,et al.. The study of Killing activity of PBMC stimulated by CpG ODN on HO8910[J]. Chinese Journal of Laboratory Diagnosis, 2007, 11(2): 163-165 |
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| Authors: | WU Fu-ju MA Xiao-yan WEI Min et al. |
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| Abstract: | Objective To study the immunotherapy role of CpG ODN(CpG oligodeoxynucleotide)on tumor.Methods PBMC(peripheral blood monouclear cells)was co-cultured with CpG ODN2006,to detect the cyto toxincity of complex on HO8910 by MTT methods.Results There is signific and difference between test group(added CpG ODN)and control group(non added CpG ODN),test group obviously raised up HO8910 killing activity.Conclusion CpG ODN may stimulate PBMC activity,and improve the dilling activity of PBMC on HO8910. |
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| Keywords: | CpG ODN |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
