过敏性鼻炎与哮喘患者血清黏附分子及白细胞介素的研究

目的探讨血清可溶性细胞间黏附分子-1（sICAM-1）、可溶性血管细胞间黏附分子-1（sVCAM-1）、可溶性E选择素（sE-selectin）、自细胞介素4（IL-4）、白细胞介素-10（IL-10）在过敏性鼻炎、哮喘、过敏性鼻炎并哮喘患者中的差异。方法103例患者按不同病因分为哮喘组33例，过敏性鼻炎组35例；过敏性鼻炎合并哮喘患者组（合并组）35例，对照组35例，4组受试者均采用双抗体夹心ELISA法检测血清中sICAM-1、sVCAM-1、sE-selectin、IL-4、IL-10的水平并进行组间比较。结果哮喘组、过敏性鼻炎组、合并组血清中sICAM-1、sVCAM-1、sE-selectin、IL-4、IL-10水平均较对照组升高（均P〈0．01）。合并组血清中sICAM-1、sVCAM-1、sE．selectin、IL-4、IL-10水平较哮喘组均增高（P〈0．05或P〈0．01），过敏性鼻炎组各指标水平同哮喘组差异不明显。结论过敏性鼻炎、哮喘有类似的炎性过程，合并组血清黏附分子及IL-4、IL-10水平升高明显。

Adhesion molecules and interlenkins in allergic rhtnitis and asthma

Objective To explore the effect of soluble intercellular adhesion molecule-1 (slCAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), soluble E-selecfin ( sE-selectin ), interleukin 4 (IL-4) and interleukin 10(IL-10) on pathogenesis of patient with Allergic rhinitis (AR) and Bronchial asthma. Methods Thirty-three patients with asthma,35 patients with AR, 35 patients with AB accompanying bronchial asthma (BA) and 35 controls were included. The concentration odd sICAM-1 ,sVCAM-1 ,sE-selectin ,IL-4,IL-10 in the sera was measured by double antibody sandwich enzyme-linked immunosorbent assay. Results The level of sICAM-1, sVCAM-1, sE-selectin ,IL-4 , IL-10 greatly increased intreatment group than control group (P <0.01). There was statistical difference of sICAM-I, sVCAM-1, sE-selectin, IL-4, IL-10 between the group of AR accompanying bronchialasthma and the group of bronchial asthma. Conclusion The study shows that both AR and asthma are characterized by means of a similar inflammatory process through upregulation of adhesion molecules. The leveh of soluble adhesion molecules, IL-4, IL-10 are significantly high in AR accompanying bronchial asthma compared with AR and asthma.