Cognitive competence at the onset of West syndrome: correlation with EEG patterns and visual function |
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Authors: | Randò Teresa Baranello Giovanni Ricci Daniela Guzzetta Andrea Tinelli Francesca Biagioni Enrico La Torre Giuseppe Epifanio Roberta Signorini Sabrina Fazzi Elisa Mercuri Eugenio Cioni Giovanni Guzzetta Francesco |
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Affiliation: | Child Neuropsychiatry, Catholic University, Rome, Italy. |
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Abstract: | The aim of this study was to evaluate cognitive development at the onset of West syndrome (WS) with regard to electroencephalogram (EEG) patterns and visual function. Twenty-five patients (14 males, 11 females) at the onset of spasms (T0) in WS and 2 months later (T1) underwent a full clinical evaluation, including neuroimaging, cognitive assessment, video-EEG, and visual function. Mean age of the patients at spasm onset was 5.9 months (SD 2.5; range 2 to 13mo). Cognitive development, assessed with Griffiths Mental Development Scales (GMDS), was generally impaired at T0 and was significantly related to visual function (p<0.001) at both T0 and T1. In general, there was a specific major impairment in the eye-hand coordination scale of the GMDS which tended to disappear after 2 months in less severe cases. At the onset of spasms, sleep EEG organization seemed to be better related to cognitive abilities than awake hypsarrhythmia. These results support a close link between visual function and cognitive competence in WS and provide additional information to improve the understanding of possible mechanisms underlying cognitive impairment. |
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