Spontaneous diabetes in eSS rats |
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Authors: | Stella M. Martínez María C. Tarrés Silvana Montenegro Roberto Milo Juan C. Picena Nora Figueroa Sol R. Rabasa |
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Affiliation: | (1) Facultad de Ciencias Médicas, Consejo de Investigaciones de la Universidad Nacional de Rosario, Argentina;(2) Instituto de Investigaciones Médicas de Rosario, Rosario, Argentina;(3) Catedra de Biología, Facultad de Ciencias Médicas, Santa Fe, 3100, 2000 Rosario, Argentina |
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Abstract: | Summary A spontaneous non-insulin-dependent diabetes in a highly inbred line of rats called eSS has been described. It is characterized by early impaired glucose tolerance worsening with age. Males are far more severely affected than females. These animals also exhibit hypertriglyceridemia and hypercholesterolemia. In spite of their hyperglycemia, eSS males have an excess of circulating plasma insulin compared with α controls. Eight-month-old eSS males were sensitive to exogenous insulin. Moreover, as the plasma insulin values decrease with age, glucose tolerance is further impaired. An improvement in the metabolic disturbances was registered in diabetic eSS males under long-term food deprivation. Histopathological examination of the pancreas revealed marked changes compared with age-matched controls. The pancreatic islet structure looked disrupted and islets became smaller and more scattered with advancing age. A diffuse glomerulosclerosis, interstitial lymphocyte infiltrates and tubular nephrosis were present in kidneys. |
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Keywords: | eSS rat Food restriction Glucose intolerance Hyperglycemia Nephropathy Plasma insulin |
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