丁基苯酞治疗轻中型颅脑损伤患者记忆及智力障碍的临床观察

目的观察丁基苯酞对轻中、型颅脑损伤患者记忆和智力障碍的治疗作用。方法将60例轻、中型颅脑损伤患者按随机数字表随机分为常规对照组和丁基苯酞（NBP）治疗组,治疗前、后分别用韦氏记忆量表和简明智力状态检查量表评估患者记忆力和智力。结果NBP治疗组治疗前、后记忆商分别为63.77±7.88和74.13±7.10,两者间差异显著（P〈0.05）;智力状态评分分别为17.33±4.52和24.60±3.71,两者间差异显著（P〈0.05）。对照组治疗前、后记忆商分别为63.87±7.90和68.57±9.02,两者间差异显著（P〈0.05）;智力状态评分分别为17.56±5.06和22.03±5.45,两者间差异显著（P〈0.05）。NBP治疗组对记忆商和智力状态评分的提高效果好于对照组,差异具有显著性（P〈0.05）。结论NBP可有效促进轻、中型颅脑损伤患者的记忆力和智力恢复。

A Clinical observation of Curative Effects of DI-3-n-butyphthalide on Dysnmesia and Dysgnosia in Patients with Mild and Moderate Traumatic Brain Injury

Objective To observe the curative effect of dl-3-n-butyphthalide （NBP） on dysmnesia and dysgnosia in the patients with mild and moderate traumatic brain injury. Methods Sixty patients with mild and moderate traumatic brain injury were randomly divided into control group and treatment group with NBP. The memory and intellect were assessed with Wechsler memory scale （WMS） and mini mental status examination （MMSE） respectively before and after the treatment in all the patients. Results The memory quotients before and after the treatment were 63.77±7.88 and 74.13±7.10 respectively and the score of MMSE before and after treatment were 17.33±4.52 and 24.60±3.71 respectively in the treatment group. The memory quotients were 63.87±7.90 and 68.57± 9.02 respectively, and the score of MMSE were 17.56±5.06, and 22.03±5.45 respectively in the eontrol group before and after the treatment. The memory quotient and score of MMSE were significantly higher in the treatment group than those in the control group after the treatment （P〈0.05）. Conclusion NBP can improve the memory and intellect in patients with mild and moderate traumatic brain injury.