Chimerism and tolerance in a recipient of a deceased-donor liver transplant |
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| Authors: | Alexander Stephen I Smith Neil Hu Min Verran Deborah Shun Albert Dorney Stuart Smith Arabella Webster Boyd Shaw Peter John Lammi Ahti Stormon Michael O |
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| Affiliation: | Centre for Kidney Research, Children's Hospital at Westmead and the Department of Paediatrics and Child Health, University of Sydney, Sydney, Australia. |
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| Abstract: | Complete hematopoietic chimerism and tolerance of a liver allograft from a deceased male donor developed in a 9-year-old girl, with no evidence of graft-versus-host disease 17 months after transplantation. The tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies. The hemolysis resolved after the gradual withdrawal of all immunosuppressive therapy. |
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