S100A13, a new marker of angiogenesis in human astrocytic gliomas |
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| Authors: | M. Landriscina G. Schinzari G. Di Leonardo M. Quirino A. Cassano E. D’Argento L. Lauriola M. Scerrati I. Prudovsky C. Barone |
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| Affiliation: | (1) Clinical Oncology Unit, Department of Medical Sciences, University of Foggia, Foggia, Italy;(2) Clinical Oncology Unit, Department of Internal Medicine, Catholic University, Rome, Italy;(3) Department of Pathology, Catholic University, Rome, Italy;(4) Department of Neurosurgery, University of Ancona, Ancona, Italy;(5) Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, USA;(6) Oncologia Medica, Università Cattolica del S. Cuore, Largo F. Vito, 1, I-00168 Roma , Italy |
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| Abstract: | S100 proteins are Ca2+-binding polypeptides involved in the tumourigenesis of several human neoplasms. S100A13 is a key regulator of the stress-dependent release of FGF1, the prototype of the FGF protein family involved in angiogenesis. Indeed, S100A13 is a copper binding protein able to enhance the export of FGF1 in response to stress in vitro and to induce the formation of a multiprotein aggregate responsible for FGF1 release. We investigated the expression of S100A13 in human astrocytic gliomas in␣relation to tumour grading and vascularization. A series of 26 astrocytic gliomas was studied to evaluate microvessel density and to assess FGF1, S100A13 and VEGF-A expression. FGF1 was equally expressed in the vast majority of tumours, whereas S100A13 and VEGF-A were significantly up-regulated in high-grade vascularized gliomas. Moreover, both S100A13 and VEGF-A expression significantly correlated with microvessel density and tumour grading. These data suggest that the up-regulation of S100A13 and VEGF-A expression correlates with the activation of angiogenesis in high-grade human astrocytic gliomas. |
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| Keywords: | Angiogenesis Brain tumours FGF1 S100A13 Tumour grading VEGF-A |
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