| 原发性甲状腺功能减退症患者血清胰岛素样生长因子-1及其结合蛋白-3的变化 |
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| 引用本文： | 金月玲,谢克俭,张琦,徐云弟,管瑜.原发性甲状腺功能减退症患者血清胰岛素样生长因子-1及其结合蛋白-3的变化[J].温州医学院学报,2005,35(1):41-42,45. |
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| 作者姓名： | 金月玲 谢克俭 张琦 徐云弟 管瑜 |
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| 作者单位： | 1. 温州医学院,检验医学院,浙江,温州,325027
2. 温州医学院,核医学甲状腺疾病诊疗室,浙江,温州,325027 |
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| 摘 要： | 目的:探讨原发性甲状腺功能减退症(甲减)患者血清胰岛素样生长因子-1(IGF-1)和胰岛素样生长因子结合蛋白-3(IGFBP-3)水平的变化.方法:采用放射免疫分析法(RIA)检测20例经左旋甲状腺素治疗前后甲减患者和20名健康人(对照组)血清IGF-1和IGFBP-3水平.结果:甲减治疗前,血清IGF-1水平(123.1±36.4)ng/ml,IGFBP-3水平(1898±630)ng/ml明显低于对照组IGF-1水平(270.7±50.1)ng/ml、IGBP-3水平(3425±935)ng/ml],差异有显著性(P＜0.01);甲减治疗后,大多数甲减缓解患者血清IGF-1和IGFBP-3水平得到恢复,IGF-1水平(239.4±45.6)ng/ml、IGFBP-3水平(3167±866)ng/ml明显高于治疗前(P＜0.01),而且与对照组比较,差异无显著性(P＞0.05).结论:甲减患者血清IGF-1和IGFBP-3水平明显下降,两者的正常调节均可能受甲状腺激素变化的影响.
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| 关 键 词： | 原发性甲状腺功能减退症 胰岛素样生长因子-1 胰岛素样生长因子结合蛋白-3 甲状腺激素 |
| 文章编号： | 1000-2138(2005)01-0041-03 |
Changes of serum insulin-like growth factors-1 and Insulin-like growth factor binding protein-3 levels in primary hypothyroidism |
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| JIN Yue-ling,XIE Ke-jian,ZHANG Qi,et al..Changes of serum insulin-like growth factors-1 and Insulin-like growth factor binding protein-3 levels in primary hypothyroidism[J].Journal of Wenzhou Medical College,2005,35(1):41-42,45. |
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| Authors: | JIN Yue-ling XIE Ke-jian ZHANG Qi |
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| Institution: | JIN Yue-ling*,XIE Ke-jian*,ZHANG Qi,et al. * School of Laboratory Medical Science,WenZhou Medical College,Wenzhou 325027 |
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| Abstract: | |
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| Keywords: | primary hypothyroidism insulin-like growth factor-1 insulin-like growth factor binding protein-3 thyroid hormone |
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