小剂量奥美拉唑与多潘立酮联合治疗功能性消化不良的疗效观察

目的评价小剂量奥美拉唑与多潘立酮联合治疗功能性消化不良的疗效。方法将100例患者随机分为2组,对照组(50例)口服多潘立酮10mg(每日3次),观察组(50例)口服奥美拉唑10mg(每日1次)和多潘立酮10mg(每日3次),疗程均为4周。结果观察组总有效率为94%,均明显优于对照组76%,且差异有统计学意义(P0.05),两组不良反应均较轻微。结论小剂量奥美拉唑与多潘立酮联合治疗能有效缓解功能性消化不良的症状,疗效明显,安全可靠。

Observation on Therapeutic Effect of Low-dose Omeprazole and Domperidone for Functional Dyspepsia

Objective To evaluate the therapeutic effect of low-dose omeprazole combined with domperidone in treating functional dyspepsia （FD）.Methods One hundred patients were randomly divided into two groups （each n=50）.The patients in control group were given oral domperidone （10 mg t.i.d.）,while the patients in observation group were given oral omeprazole （10 mg q.d.） and domperidone （10 mg t.i.d.）.And both the courses of treatment lasted for 4 weeks.Results The total effective rate of observation group was 94% which was significantly superior to that of control group （76%）,and there were statistically significant differences between the two groups （P〈0.05）.The adverse reactions of both groups were mild.Conclusions The combination therapy of low-dose omeprazole and domperidone can effectively relieve the symptoms of functional dyspepsia,with obvious efficacy,security and reliability.