凝血与纤溶系统水平对围术期产妇弥漫性血管内凝血的诊断价值

目的：研究凝血与纤溶系统水平对围术期产妇弥漫性血管内凝血（DIC）的诊断价值。方法选择2007年10月-2012年10月在我院接受治疗的 DIC 产妇40例（DIC 组），选取在我院体检正常的健康孕妇40例（健康孕妇组），同时选取40例健康非孕妇（健康非孕妇组）为研究对象，对三组凝血与纤溶指标进行检测并比较分析。结果健康孕妇组与健康非孕妇组比较显示，PLT、FIB 明显升高，PT、TT、APTT 及 D-D 二聚体水平明显降低，差异有统计学意义（P ＜0．05）；DIC 组与健康孕妇组比较发现，PLT、FIB 明显降低，而 PT、TT 和 APTT 明显延长，D-D 含量明显升高，差异具有统计学意义（P ＜0．05）；DIC 组与健康非孕妇组比较，PLT、FIB 降低，而 PT、APTT 及 D-D 二聚体水平升高，差异有统计学意义（P ＜0．05）。除 APTT 与 PT 之间无关外，DIC 组组内其他的凝血与纤溶指标都具有一定的相互关系（P ＜0．05）。结论凝血与纤溶系统水平对于围术期产妇 DIC 具有重要的诊断意义，APTT、PT 和 TT 水平的升高提示患者凝血功能下降，而 D-D 的升高则说明纤溶的发生。

Clinical diagnostic value of coagulation and fibrinolysis system level on perioperative maternal with DIC

Objective To investigate the clinical diagnostic value of coagulation and fibrinolysis system level on perioperative maternal with DIC.Methods Selected 40 cases of pregnant women with DIC（DIC group）from 2007 October to 2012 October,40 cases of healthy pregnant women（healthy pregnant women group）,and 40 cases of healthy non-pregnant women（healthy non-pregnant women group）,the blood coagulation and fibrinolysis indexes between three groups were detected and compared.Results Compared with those of the healthy non-pregnant women group,the PLT,FIB of the healthy pregnant women group significantly increased,and PT,TT,APTT and D-D two dimer level significantly reduced,the difference was statistically significant （P 〈0.05）.DIC group compared with healthy pregnant women group showed that PLT and FIB were significantly lower,while PT,TT,APTT,D-D wree higher,the difference was statistically significant （P 〈0.05）.DIC group compared with healthy non-pregnant women group showed that PLT and FIB were significantly lower,while PT,APTT,D-D wree higher,the difference was statistically significant （P 〈0.05）.In addition to no clearance between APTT and PT,DIC group in other blood coagulation and fibrinolysis have certain relations （P 〈0.05）.Conclusion Coagulation and fibrinolysis system level have important diagnostic implications for perioperative maternal with DIC,APTT,PT,TT increased significantly indicating that the coagulation function decreased and D-D increased indicating the fibrinolysis occurs.