老年溃疡性结肠炎患者的临床、内镜和病理分析

目的 探讨老年溃疡性结肠炎患者的临床、内镜和病理特点及与非老年患者的差异.方法 收集分析2000年1月至2008年12月在我院诊断为溃疡性结肠炎349例患者的相关资料,对老年(≥60岁)溃疡性结肠炎患者与非老年(<60岁)溃疡性结肠炎患者的临床表现、内镜和病理特点进行比较分析.结果 老年组68例,男性37例,女性31例,年龄(68.54±7.16)岁;非老年组281例,男性150例,女性131例,年龄(42.38±10.88)岁.老年溃疡性结肠炎患者中腹泻、腹痛和便血等临床表现的发生率与非老年患者均无显著性差异(P>0.05).老年组病情轻度患者占60.3%,较非老年组多(P<0.05).内镜下老年组溃疡性结肠炎病变范围以直肠、直乙状结肠及左半结肠多见,但与非老年组相比差异无统计学意义(P>0.05).在病理学上老年组异型增生的发生率显著高于非老年组(P<0.05).结论 老年溃疡性结肠炎患者的病情相对较轻,但异型增生发生率较高,应加以重视.

Analysis of the clinical,endoscopic and pathological features between the aged and non-aged patients with ulcerative colitis

Objective To analyze the clinical, endoscopic, and pathological features of aged patients with ulcerative colitis and the difference between the aged and non-aged patients. Methods The clinical, endo-scopic, and pathological data from 349 ulcerative colitis patients admitted in Huadong Hospital from January 2000 to December 2008 were reviewed and analyzed retrospectively. The patients were divided into two groups: aged group (≥60 years) and non-aged group (<60 years). Results Of the 349 patients, 68 patients were classified as aged group [male to female: 1.19: 1, mean age: (68.54±7.16) years old]. The other 281 pa-tients were classified as non-aged group [male to female: 1.15: 1, mean age: (42.38±10.88) years old].There was no significant difference in the incidence of clinical manifestations such as diarrhea, celialgia and he-mafecia, etc. (P>0.05) between the two groups. The disease of aged patients was less severe than that of the non-aged patients (P<0.05). The lesions of the aged patients were more located at the rectum, sigmoid co-lon, and left hemicolon, but no significant difference in the extent of disease was found between the two groups (P>0.05). The occurrence of dysplasia in the aged patients was higher than that in the non-aged patients (P<0.05). Conclusion The degree of severity of the aged patients with ulcerative colitis is comparatively mild, but the occurrence of dysplasia is more frequent.