特发性高钙尿症患儿红细胞膜钙泵活性的测定

目的探讨小儿特发性高钙尿症红细胞膜钙系活性变化特点及其意义。方法特发性高钙尿症３８例，２０名健康儿童为对照组。以红细胞膜（Ｃａ＋＋－Ｍｇ＋＋）－ＡＴＰ酶和（Ｎａ＋－Ｋ＋）－ＡＴＰ酶同步测定法检测红细胞膜钙泵活性，并对结果进行统计学分析。结果肠吸收型特发性高钙尿症红细胞膜钙泵活性明显高于对照组（Ｐ＜０．０１），而肾脏漏出型却明显低于正常对照组（Ｐ＜０．０５）。结论特发性高钙尿症患儿存在细胞膜钙泵活性异常，此可能与其发病机制密切相关。

Measurement of Erythrocyte Membrane Calcium Pump Activity in Children With Idopathic Hypercalciuria

Objective To search for the changes of erythrocyte membrane calcium pump activity and it's significance in child patients with idiopothic hypercalciurin (IH).Methods There were 38 children with IH in IH group and 2) healthy chillren in control groap The erythrocytc membrane cslcium pump activity was determined by synchronic assay.of (Ca -Mg ) ATP enzpme cud (Na -K ) -ATP enzyme on erythrocyte membrane.The results were analysed statisticatly,Results In comparis on to normal control group, erythrocyte membrane calcium pump, activity in childpatients with intestinal absorptive type IH was significantly higher (P<0.01), whereas it .was lowerin child patients with renal leaky type IH (P<0.05).Conclusions The children with IH hod abnormality of cell membrane calcium pump activity.The pathogenesis of IH was closely related to abnormality of cell membrane calcium pump activity.