难治性癫痫的病理学与多药耐药基因表达的研究

目的观察难治性癫痫患者的临床表现、手术获取脑组织的病理变化和多药耐药基因的表达并分析其相互关系。方法分析26例不同病因难治性癫痫患者的临床特征、术前评估、术中切除的脑组织在光镜和电镜下的病理变化以及多药耐药基因蛋白(MDR1)和胶质纤维酸性蛋白(GFAP)的表达。结果不同病因的难治性癫痫患者在发病年龄、癫痫发作形式等临床表现中存在着共同特征,都有神经元退行性损伤、反应性胶质细胞增生和MDR1高表达等病理学改变。结论不同病因的难治性癫痫患者存在着某些类似的病理学表现。

The Study on Pathology and Expression of MDR1 in Human Intractable Epilepsy

Objective To study the clinical characteristics,the pathological features,and the expression patterns of MDR1 and GFAP in intractable epilepsy patients with varied etiologies and to analyze the relations between clinical and pathological performances among those cases.Methods The clinical characteristics of strictly selected 26 intractable epilepsy patients were conduded and the pathological changes including the expression of MDR1 and GFAP from surgically resected tissues were analyzed systematically observed under light and electron microscopy.The relations between the clinical and pathological manifestutions of each subject were studied.Results There were certain common clinical characteristics,such as the onset of age and main types of seizure,which could be concluded in all studied cases,although the etiology of each subject may vary.Meanwhile some pathological changes including neuronal degeneration,reactive proliferation of astrocyte with over expression of GFAP and MDR1 appeared as the common features among all cases.Conclusion There are common pathological characteristics in the patients with intractable epilepsy,although the etiologies of them may vary.It may be resulted from recurrent epileptic ictus.