血管内皮生长因子与慢性阻塞性肺疾病

慢性阻塞性肺疾病是一个发病率和死亡率都很高的慢性疾病，其发病机制涉及肺内细胞的凋亡，肺实质细胞的减少，炎性细胞的浸润和气道、血管的重构。血管内皮生长因子作为一个可特异作用于内皮细胞，调节血管内皮细胞生长、分化、修复及发挥功能的重要因子，与慢性阻塞性肺疾病的发生有着密切的联系。

Vascular endothelial growth factor and chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease(COPD) is a chronic inflammatory disease with high morbidity and mortality.Its pathogenesis involves to the lung cell's apoptosis,decrease of the parenchyma cell,inflammatory cell's infiltration,and remodeling of the airway and blood vessel.Vascular endothelial growth factor(VEGF) is an important regulator of angiogenesis,repair and a specific mitogen for endothelial cells.Many reports indicate that VEGF may contribute to the pathogenesis of COPD.