Characteristics of transplanted mouse myeloproliferative disease developed after repeated injections of granulocytic colony-stimulating factor |
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Authors: | A E Bigildeev N V Sats A L Grishchuk I N Nifontova D A Svinareva N J Drize |
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Institution: | (1) Laboratory of Hemopoiesis Physiology, Hematological Research Center, Russian Academy of Medical Sciences, Moscow, Russia |
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Abstract: | Transplanted myeloproliferative disease developed in mice against the background of repeated injections of granulocytic CSF
was characterized using morphological and molecular biological methods. It was demonstrated that transplanted myeloproliferative
disease had a non-viral nature and is probably induced by repeated injections of granulocytic CSF. Tumor cells actively populate
the liver of sick animals, which leads to their rapid death. Expression of Myc, Abl, G-CSF, and MPO genes is enhanced, which
is typical of myeloid neoplastic transformation.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 2, pp. 234–240, February, 2008 |
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Keywords: | granulocytic colony-stimulating factor myeloproliferative disease tumor transformation gene expression |
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