同型半胱氨酸与新诊2型糖尿病下肢血管病变的关系

目的探讨同型半胱氨酸（Hcy）与新确诊2型糖尿病（T2DM）下肢血管病变的关系。方法测定正常对照组（NC）、新确诊T2DM但无下肢血管病变组（T2DM）、新确诊T2DM并伴有下肢血管病变组（T2DM＋LLVD）Hcy和踝肱指数（ABI）的变化。结果与NC组相比，T2DM组和T2DM＋LLVD组BMI、WHR、SBP、TC、TG、LDL-C、HbA1c显著升高，HDL-C显著下降；与T2DM组相比，T2DM＋LLVD组Hcy、LDL-C、HbA1c显著升高，HDL-C显著下降。Logisitic回归分析显示Hcy是新确诊T2DM并伴有下肢血管病变的独立危险因子。结论Hcy升高是促使新确诊T2DM并发下肢血管病变的独立危险因素。

Relationship between homocysteine level and peripheral artery disease in patients with newly-diagnosed type 2 diabetes

Objective To observe the association between homocysteine （Hcy）level and low limb vascular disease（LLVD） in newly-diagnosed type 2 diabetic patients. Methods The study subjects were divided into three groups ： control group （NC）, newly-diagnosed type 2 diabetes group without peripheral artery disease （T2DM） and peripheral artery disease with newly-diagnosed type 2 diabetes group （T2DM-~-LLVD）. Both Hcy and the anklebrachial index（ABI） were measured in three groups. Results Compared with NC group, clinical parameters of body mass index, waist-to-hip ratio, systolic blood pressure, total cholesterol （TC）, triglycerides （TG）, low density lipoprotein-cholesterol（LDL-C） ,and glycated hemoglobin A1C （HbA1 c） increased markedly,and the content of high density lipoprotein-cholesterol （HDL-C） was markedly lower in both T2DM and T2DM＋LLVD groups. In T2DM ＋LLVD group the contents of Hcy,LDL-C and HbA1c were markedly higher than in T2DM group,but the content of HDL-C decreased significantly. Hcy was independently associated with the development of peripheral artery disease in newly-diagnosed type 2 diabetic patients by logisitic regression analysis. Conclusions Increased Hcy is an independent risk factor for peripheral artery disease in newly-diagnosed type 2 diabetes.