小剂量米非司酮治疗子宫肌瘤

目的：了解小剂量米非司酮治疗子宫肌瘤的效果和安全性。方法：有症状的子宫肌瘤患者２８例，口服米非司酮每日１０ｍｇ，连续３个月；治疗期间每月用Ｂ超测量子宫和肌瘤体积，并测血红蛋白、肝肾功能及询问一般情况。结果：治疗后所有病人均闭经，腹痛消失，肌瘤体积缩小４２．６％，贫血均得以纠正，病人一般情况明显好转，无明显副作用。结论：每日１０ｍｇ剂量米非司酮治疗子宫肌瘤是一种安全、有效的方法，适用于手术前和围绝经期子宫肌瘤患者。

HTERINE LEIOMYOMATA IN RESPONSE TO LOW DOSE MIFEPRISTONE

Objective:To examine the uterine leiomyomata in response to low dose mifepristone of dailyadministration. Methods:Administration of mifepristone l0mg/d for a period of 3 months to 28 patients with symptomatic uterine leiomyomata. Ultrasound examination were obtained monthly during treat-ment as a measure of leiomyomata and uterine volume. Hemoglobin and the functions of liver and kid-ney were monitored monthly. Results:Amenorrhea was induced in all patiens during treatement. Pelvic pain and dysmenorrhea disappeared.Leiomyomata voltime decreased 42.6%(P>0.001)after 3 months compared to pretreatment.All anemia were corrected after 3 months.No side effects but mild atypical hot flashes and joint pain appeared. Conclusion :Low dose mifepristone is well tolerated,safe and effective, Thus it may prove to be a novel mode of management for uterine leiomyomata for preop-eration and perimanopaus.