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Effects of melatonin and propranolol on sleep of the rat |
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| Authors: | Wallace B. Mendelson J. Christian Gillin Susan D. Dawson Alfred J. Lewy Richard Jed Wyatt |
| Abstract: | Melatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times. |
| Keywords: | melatonin l-propranolol sleep REM sleep |
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