| 破血化瘀药三棱莪术对大鼠肺纤维化干预作用的实验研究 |
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| 引用本文： | 王英豪,姚欣,邱颂平,林静瑜,周春权.破血化瘀药三棱莪术对大鼠肺纤维化干预作用的实验研究[J].中国中医药科技,2011,18(3):188-189,220,176. |
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| 作者姓名： | 王英豪 姚欣 邱颂平 林静瑜 周春权 |
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| 作者单位： | 1. 福建中医药大学药学院·福州,350108
2. 福建省中医药研究院·福州,350003 |
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| 基金项目： | 福建省教育厅科技资助项目 N0.JA05277福建省高校中西医结合基础重点实验室(福建中医学院)开放课题基金·陈可冀中西医结合发展基金资助项目No.CKJ2008011、ZXY2008007 |
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| 摘 要： | 目的：观察破血化瘀药三棱莪术对肺纤维化大鼠肺形态学、活化部分凝血活酶时间、凝血酶原时间、趋化因子MCP-1的影响。方法：大鼠气管内注入博来霉素造模。随机分为正常对照组、模型组、泼尼松组、三棱莪术高剂量组和低剂量组,造模次日起给药,于第28天处死大鼠,观察肺形态学改变,测定血浆活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）及ELISA测定血浆趋化因子MCP-1的含量。结果：模型组大鼠肺泡壁显著增厚,肺纤维化形成;给药组肺组织纤维化较模型组均减轻。模型组大鼠血浆MCP-1含量较正常组明显增高,与模型组比较,三棱莪术高剂量组、三棱莪术低剂量组、泼尼松组大鼠血浆MCP-1含量明显降低（P〈0·05）。模型组大鼠APTT时间较正常组明显缩短,与模型组比较,三棱莪术高剂量组、泼尼松组APTT时间显著延长（P〈0·01）;三棱莪术低剂量组APTT时间延长（P〈0·05）。结论：破血化瘀药三棱、莪术能有效抑制博来霉素引起的肺纤维化形成。
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| 关 键 词： | 肺纤维化/中医药疗法 三棱/治疗应用 莪术/治疗应用 大鼠 |
Experimental Study on Intervention Effect of Rhizona Spaeganii and Rhizoma Curcumae on Rats' Pulmonary Fibrosis |
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| WANG Yinghao,YAO Xin,QIU Shongping.Experimental Study on Intervention Effect of Rhizona Spaeganii and Rhizoma Curcumae on Rats' Pulmonary Fibrosis[J].Chinese Journal of Traditional Medical Science and Technology,2011,18(3):188-189,220,176. |
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| Authors: | WANG Yinghao YAO Xin QIU Shongping |
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| Institution: | WANG Yinghao,YAO Xin,QIU Shongping(Fujian University of Traditional Chinese Medicine,Fuzhou 350108) |
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| Abstract: | Objective:To observe the intervention effect of rhizome sparganii and rhizome curcumae on rats' pulmonary fibrosis.Methods:The models were intratracheal injected bleomycin to establish.Rats were randomly divided into normal,model,prednisone,high and low dose rhizome sparganii and rhizome curcumae groups,each group was given the corresponding medicine for 28 days.The pathological changes of rat's lung were observed,the APTT and PT were recorded,the plasma MCP-1 content was determined.Results:The alveolar wal... |
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