淫羊藿总黄酮对摘除卵巢大鼠骨质疏松症防治作用 |
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引用本文: | 季晖,刘康,龚晓健,李绍平,章明放. 淫羊藿总黄酮对摘除卵巢大鼠骨质疏松症防治作用[J]. 中国骨质疏松杂志, 2001, 7(1): 4-8 |
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作者姓名: | 季晖 刘康 龚晓健 李绍平 章明放 |
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作者单位: | 1. 中国药科大学药理学教研室 2. 天津医科大学病理学教研室 |
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基金项目: | 江苏省科委应用基础基金资助项目 |
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摘 要: | 用摘除卵巢法结合低钙饲料建立大鼠骨质疏松模型。淫羊藿总黄酮在75~300mg/kg剂量范围内连续给药3个月,与模型组大鼠比较,能明显提高大鼠股骨表观面密度(W/LD)和骨密度(BMD)而不升高子宫系数及血清雌二醇(s-E
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关 键 词: | 骨质疏松症; 淫羊藿总黄酮; 去卵巢; 骨密度; 骨形态计量学 |
Effects of Epimediumkoreanum flavoids on osteoporosis in ovar iectomized rats |
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Abstract: | Ovariectomized rat models fed with low calcium diet we r e used to evaluate the effects of total flavoids of Epimedium koreanum Nakai (EK F) on osteoporosis.Three doses of EKF(75,150 and 300 mg/kg)were given orally for three months.Compared with control model group,EKF could increase femur W/LD(P <0.05) without raising the uterus index and serum estradiol level.300 mg/kg E KF decreased serum ALP in rats(P<0.05),and increased femur density(P<0 .05).Bone histomorphometry showed that EKF decreased TRS% and TFS% at the dose of 300 mg/kg,but increased TBV%. |
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