Silicon and aluminium interactions in haemodialysis patients |
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| Authors: | Parry, R Plowman, D Delves, H Roberts, N Birchall, J Bellia, J Davenport, A Ahmad, R Fahal, I Altmann, P |
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| Affiliation: | Wessex Renal & Transplant Unit, St Mary's Hospital, Portsmouth, UK; Department of Chemical Pathology, Chase Farm Hospital, Enfield, London, UK; Trace Element Unit, Clinical Biochemistry, Southampton General Hospital, Southampton, UK; Department of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool, UK; Unit of Inorganic Chemistry and Materials Science, Department of Chemistry, Keele University, Keele, UK; Royal Free Hospital, London, UK; Department of Renal Medicine, Royal Liverpool University Hospital, UK; Corresponding author at: Oxford Renal Unit, The Churchill, Oxford Radcliffe Hospital, Oxford OX3 7LJ, UK |
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| Abstract: | Background: Aluminium toxicity in dialysis patients iswell described. Aluminium has a close chemical affinity with silicon.Silicon may have a role in protection against aluminium toxicity.Methods: We measured serum aluminium and siliconlevels from haemodialysis patients from four different centres.Results: Though no relationship was seen across allcentres combined, in one centre there was a reciprocal relationship inpatients on home haemodialysis (who did not require reverse osmosis).Median (range) aluminium levels were higher, 2.2 (0.4-9.6) &mgr;mol/lwhen serum silicon was less than 150 &mgr;mol/l, and lower, 1.1(0.2-2.8) &mgr;mol/l when serum silicon levels were greater than 150&mgr;mol/l (P=0.03). Conclusions: In patientstreated by haemodialysis without reverse osmosis high serum siliconconcentrations were associated with lower serum aluminium concentrationsthan those with low serum silicon. Further work needs to confirm apreventative role for silicon in the accumulation and subsequent toxicityof aluminium in dialysis patients. |
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