Combined surgery and radiation therapy for squamous cell carcinoma of the hypopharynx |
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| Authors: | DENNIS H. KRAUS MD MICHAEL J. ZELEFSKY MD HEIDI A.J. BROCK MD JERRY HUO MD LOUIS B. HARRISON MD JATIN P. SHAH MD From the Head Neck Service |
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| Affiliation: | DENNIS H. KRAUS MD, MICHAEL J. ZELEFSKY MD, HEIDI A.J. BROCK MD, JERRY HUO MD, LOUIS B. HARRISON MD, JATIN P. SHAH MD,From the Head,Neck Service, Department of Surgery (Drs. Kraus, Brock, Huo,Shah),the Brachytherapy Services, Department of Radiation Therapy (Drs. Zelefsky,Harrison), Memorial Sloan-Kettering Cancer Center. |
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| Abstract: | Squamous cell carcinoma of the hypopharynx remains a highly lethal disease. This article documents our experience with 132 patients undergoing surgical management of squamous cell carcinoma of the hypopharynx, of whom 80% received postoperative radiation therapy. Local-regional control was obtained in 61% of the patients. Five-year overall and disease-free survival rates were 30% and 41%, respectively. Prognosis was better in patients with limited disease: local disease permitting larynx-sparing surgery, N0/N1 clinical neck, and stage I/II/III disease. Cancer of the hypopharynx remains an aggressive entity associated with poor prognosis. Novel strategies stressing improved local-regional control with prevention of distant metastasis are warranted. (Otolaryngol Head Neck Surg 1997; 116: 637-41.) |
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