| 佛司可林两个类似物对饮水导致的人眼压升高的影响 |
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| 引用本文： | 杨为民 李新华 等. 佛司可林两个类似物对饮水导致的人眼压升高的影响[J]. 眼科研究, 2001, 19(6): 556-559 |
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| 作者姓名： | 杨为民 李新华 等 |
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| 作者单位： | 杨为民（昆明医学院天然药物药理重点实验室,昆明650031） 李新华（昆明医学院天然药物药理重点实验室,昆明650031） 陈植和（昆明医学院天然药物药理重点实验室,昆明650031） 聂玲辉（昆明医学院天然药物药理重点实验室,昆明650031） 李玲（昆明医学院天然药物药理重点实验室,昆明650031） 雷伟亚（昆明医学院天然药物药理重点实验室,昆明650031） |
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| 基金项目： | 本课题受云南省自然科学基金资助(基金编号：95C070M) |
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| 摘 要： | 目的实验观察佛司可林两个类似物,即isoforskolin(isoF),deacetylforskolin(deaF),对饮水导致急性人眼压升高的影响.方法按随机双盲法设计,将佛司可林两个类似物配成的滴眼液分别滴人l眼,相应的溶媒滴入另眼.让受试者饮水(14ml/kg)造成急性人眼压升高.给药前后用气动式眼压计测定眼压值,观察眼压变化.结果表明isoF(0.5%)及deaF(1.0%)均有抑制作用,最大抑制率分别为¨.4%及12.0%,并且副作用小.结论实验证明isoF(0.5%)及deaF(1.0%)抑制饮水导致急性人眼压升高.
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| 关 键 词： | 眼压升高 饮水 佛司可林类似物 isoF deaF |
| 修稿时间： | 2000-04-20 |
Effects of twoforskolin analogs on the elevation of ocular pressure in human |
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| Abstract. Effects of twoforskolin analogs on the elevation of ocular pressure in human[J]. Chinese Ophthalmic Research, 2001, 19(6): 556-559 |
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| Authors: | Abstract |
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| Abstract: | ObjectiveTo investigate the effects of two compounds,isoforskolin (isoF) and deacetylforskolin (deaF) on the acute increase of intra ocular pressure (IOP) induced by water drinking (14 ml/kg) in healthy subjects when topically administered.MethodsThe study was carried out in double blind and randomized healthy subjects.Drops of the two drugs were instilled into one eye while the corresponding vehicle was administrated into the contralateral eye.IOP was measured with pneumatonometer before and after administration respectively.ResultsThe results showed both isoF (0 5%) and deaF (1 0%) decreased the acute elevation of IOP induced by water drinking with the maximal inhibitory rates of 11 4 and 12 0% respectively.The drugs were well tolerated by subjects.Conclusion IsoF and deaF are effective on inhibition of the IOP increase. |
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| Keywords: | forskolin analogs human intraocular pressure |
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