盐酸川芎嗪对婴幼儿先天性心脏病体外循环术后白介素-6、白介素-8及中性粒细胞的影响

目的：探讨盐酸川芎嗪对婴幼儿先天性心脏病体外循环（CPB）术后细胞因子IL-6、IL-8及中性粒细胞的影响。方法：40例经CPB行先天性心脏病手术的患儿随机分为观察组20例，对照组20例。观察组术前1h静脉给予川芎嗪（5mg／kg），对照组给予同等剂量生理盐水。分别在气管插管后10min（T1）、转流后5min（T2）、手术结束时（T3）、手术后2h（T4）、手术后24h（T5）采集动脉血3mL，离心取血浆，通过酶联免疫吸附法（ELISA）检测致炎细胞因子IL-6、IL-8血浆浓度，同时对每一时点中性粒细胞计数。结果：两组IL-6在手术结束时（T3）、术后2h（T4），IL-8在手术结束时（T3）升高显著（P〈0．05），而对照组升高更显著（P〈0．01），在手术后24h（L）均下降并接近正常，但IL-6对照组仍比观察组偏高；中性粒细胞CPB术后升高，但两组间差异无统计学意义。结论：术前应用盐酸川芎嗪对婴幼儿先天性心脏病CPB术后致炎细胞因子IL-6、IL-8有抑制作用。

The Effect of Ligustrazine Hydrochloride on IL-6,IL-8 and Neutrophil after Cardiopulmonary Bypass in Infants with Congenital Heart Disease

Objective:To study the effect of Ligustrazine Hydrochloride on IL-6,IL-8 and neutrophil after cardiopulmonary bypass(CPB).Methods: Forty infants with congenital heart disease were randomly divided into two groups: 20 cases in the observing group and 20 cases in the control group.With the ELISA,the plasma concentrations of the proinflammatory cytokines such as IL-6,IL-8 and neutrophil were measured at the time points of T1(10 min after the trachea cannula),T2(5 min after bypass),T3(time of the surgery termin...